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Table of Contents

• ↓ A global map of the Zika virus phosphoproteome reveals host-driven regulation of viral particle release and cytopathogenicity
• ↓ The quiet reservoir: Understanding Shiga toxin Escherichia coli O157:H7 colonization in cattle
• ↓ Longitudinal assessment of functional antibodies to a novel influenza virus strain across age groups
• ↓ How resistance-nodulation-division (RND) efflux pumps contribute to virulence
• ↓ An orthoflavivirus inhibitor targeting multifunctional NS2A protein, a previously unidentified target
• ↓ A bacterial-type cardiolipin synthase in Plasmodium spp. supports mitochondrial respiration and is important for liver stage maturation
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"PLOS Pathogens publishes Open Access research and commentary that significantly advance the understanding of pathogens and how they interact with host organisms."

"Zika virus can cause neurological complications and birth defects in humans. We have a limited understanding of how the function(s) of Zika virus proteins are regulated or the true range of functions each protein carries out. In this study the authors created a comprehensive “map” of how human enzymes attach chemical tags—specifically phosphate and ubiquitin groups—to Zika virus proteins."

"In the US, Shiga toxin-producing Escherichia coli (STEC) remains a major food safety concern, causing an estimated 357,000 illnesses annually with O157:H7 representing the most clinically significant serovar. Cattle are the primary reservoir of O157:H7, and approximately 20% of illnesses are linked to beef. As foodborne outbreaks linked to O157:H7 occur, understanding how this pathogen colonizes cattle is critical for improving animal management and public health."

"Most people have antibodies from past flu infections or vaccinations that can recognize new influenza strains. This study found that these broadly reactive antibodies were present across all age groups and were boosted by infection or vaccination, suggesting vaccination could provide early protection against severe disease when new influenza viruses emerge."

Key Topics & Focus Areas for plospathogens.org:

A global map of the Zika virus phosphoproteome reveals host-driven regulation of viral particle release and cytopathogenicity

The quiet reservoir: Understanding Shiga toxin Escherichia coli O157:H7 colonization in cattle

Longitudinal assessment of functional antibodies to a novel influenza virus strain across age groups

How resistance-nodulation-division (RND) efflux pumps contribute to virulence

An orthoflavivirus inhibitor targeting multifunctional NS2A protein, a previously unidentified target

A bacterial-type cardiolipin synthase in Plasmodium spp. supports mitochondrial respiration and is important for liver stage maturation