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• ↓ Mind the gap: An embedding guide to safely travel in sequence space
• ↓ Extracting host-specific developmental signatures from longitudinal microbiome data
• ↓ Integrative modelling of innate immune response dynamics during virus infection
• ↓ Towards modelling phage therapy
• ↓ Ten simple rules for writing a peer review
• ↓ Environmental “knees” and “wiggles” as strong stabilizers of species’ range limits set by interspecific competition
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"Given the amino acid sequence of the original enzyme and a set of residues for which the local environment should be conserved, i.e., the catalytic site, the author's approach generates mutants that differ vastly in the overall sequence while retaining the geometry of the conserved region, thereby representing promising candidates for further experimental screening"

"Longitudinal microbiome studies provide critical insights into microbial community dynamics and their relation to host health. Tensor decompositions offer a powerful framework for the unsupervised analysis of such data, yielding interpretable low-dimensional temporal patterns. However, existing approaches based on the CP model assume common temporal dynamics for all subjects and therefore cannot capture subject-specific trajectories."

"Understanding the dynamic interaction between the viral life cycle and immune signaling is crucial to designing effective antiviral strategies. Although significant progress has been made, quantitative models that can accurately capture the intricate interactions and the intertwined dynamics during viral infection of cells remain missing."

"Patients with dangerous antibiotic-resistant bacteria have been treated with mixtures of bacteriophages — viruses that infect bacteria. This treatment is highly personalized because the right phages must be selected for each patient’s infection. Since bacteria quickly evolve resistance to phages, it is often unclear why a treatment works or fails, and how to design the best phage combinations."

Key Topics & Focus Areas for ploscompbiol.org:

Mind the gap: An embedding guide to safely travel in sequence space

Extracting host-specific developmental signatures from longitudinal microbiome data

Integrative modelling of innate immune response dynamics during virus infection

Towards modelling phage therapy

Ten simple rules for writing a peer review

Environmental “knees” and “wiggles” as strong stabilizers of species’ range limits set by interspecific competition