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"The debate over whether to use anaesthetics in surgery, dentistry and obstetrics might now seem of merely historical interest. Yet it is worth briefly recalling some of the arguments used against the introduction of pain-free surgery raised by a minority of 19th century churchmen, laity and traditionally-minded physicians. For their objections parallel the arguments put forward in the early 21st century against technologies for the alleviation or abolition of "emotional" pain - whether directed against the use of crude "psychic anaesthetisers" like today's SSRIs, or more paradoxically against the use of tomorrow's mood-elevating feeling-intensifiers i.e. so-called "empathogen-entactogens", hypothetical safe and long-acting analogues of MDMA."

"It's worth recalling too that early critics of surgical and obstetric anaesthesia weren't (all) callous reactionaries or doctrinaire religious fundamentalists. Nor are all contemporary critics of the use of pharmacotherapy to treat psychological distress. The doubters, critics and advocates of caution were right to consider the potential diagnostic role of pain - and to emphasise that the risks, mechanisms and adverse side-effects of the new anaesthetic procedures were poorly understood. In Victorian Britain, around 1 in 2500 people given chloroform anaesthesia died directly in consequence. Around 1 in 15,000 died as a direct result of being administered ether. This statistic pales beside the proportion that died from post-surgical infection; but it compares with the present-day mortality figure of 1 in around 250,000 people who die as a direct result of undergoing surgical anaesthesia in the UK. Safe and sustainable total anaesthesia that is 100% reliable - and reliably reversible - is as hard to achieve as safe and sustainable analgesia, euthymia, or euphoria. Yet the technical and ideological challenges ahead in banishing suffering from the world shouldn't detract from the moral case for its abolition."

"The concept of pain-relief and even total insensibility for surgery wasn't original or unfamiliar. However, for thousands of years its reliable prospect had seemed impossibly utopian - as unrealistic as a future of lifelong bliss seems at present."

"The single or combined use of stupefying agents such as ethyl alcohol, mandragora, cannabis and opium to deaden the sensibilities prior to surgery had been practised in classical antiquity. Herodotus (c.484-c.432 BC) relates how the Scythians induced stupor by inhalation of the vapours of some kind of hemp, a remarkable if apocryphal feat in the low-THC era before superskunk."

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