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Table of Contents

• ↓ Why Do Myesthenia Gravis Patients Live Five Years Longer than the General Population?
• ↓ How Tauopathy Promotes Mitochondrial Dysfunction, and Prospects for Sabotaging that Mechanism
• ↓ Mechanisms of Neuroprotection Arising from Exercise
• ↓ Is it Reasonable to Say that Obesity Accelerates Aging?
• ↓ Targeting Senescent Cells to Treat Age-Related Chronic Pulmonary Disease
• ↓ Reviewing the State of Aging Clocks for the Brain
• ↓ Top Alternatives to fightaging.org

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"Do you want to live a longer life in good health? Simple practices can make some difference, such as exercise or calorie restriction. But over the long haul all that really matters is progress in medicine: building new classes of therapy to repair and reverse the known root causes of aging. The sooner these treatments arrive, the more lives will be saved. Find out how to help »"

"Myesthenia gravis is a rare autoimmune condition in which a specific receptor needed for nerve impulses to pass through the neuromuscular junction to active muscle fibers is blocked or destroyed by immune activity. This leads to muscle weakness that varies over time, and can progress to be life-threatening in a minority of cases. The prognosis is good for the majority of patients, however. While distressing, the condition affects only parts of the body, and doesn't cause pathology (such as chronic inflammation) that directly contributes to other conditions or the pace of aging. The existing therapies are helpful for most patients, and are improving over time. If forced to choose one presently incurable neuromuscular autoimmune condition to suffer, this would be strong contender. The others tend towards being much worse."

"A very interesting paper was published recently. Researchers set out to compare the epidemiology of patients with myesthenia gravis and multiple sclerosis using data in four US state databases. Both are incurable autoimmune conditions that affect muscle function, the second being far worse than the first in terms of loss of vital function and patient outcomes. Along the way, the researchers made the unexpected discovery that myesthenia gravis patients live five years longer than the general population, noting that "this observation should be interpreted as hypothesis-generating." Meaning that there is no obvious reason as to why this would be the case."

"How long can sizable differences in life expectancy between groups hide from the attention of those who seek to understand why exactly it happens? There are analogous examples, such as the clinical trial showing a five year survival advantage over the general population in osteoporosis patients who took bisphosphonate drugs, for example. It later turned out that those drugs may be senolytic, reducing the burden of senescent cells, but the topic is by no means closed, nor even really all that widely known or eagerly investigated."

Key Topics & Focus Areas for fightaging.org:

Why Do Myesthenia Gravis Patients Live Five Years Longer than the General Population?

How Tauopathy Promotes Mitochondrial Dysfunction, and Prospects for Sabotaging that Mechanism

Mechanisms of Neuroprotection Arising from Exercise

Is it Reasonable to Say that Obesity Accelerates Aging?

Targeting Senescent Cells to Treat Age-Related Chronic Pulmonary Disease

Reviewing the State of Aging Clocks for the Brain