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Table of Contents

• ↓ Introducing 
ESM Cambrian
• ↓ Enabling scientists to understand, imagine, and create proteins.
• ↓ Creating proteins beyond nature.
• ↓ ESM3 simultaneously reasons over the fundamental properties of a protein: sequence, structure, and function.
• ↓ A model trained across all of evolution.
• ↓ Start working with ESM3
• ↓ Top Alternatives to evolutionaryscale.ai

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"Defining a new frontier in protein sequence modeling, ESM Cambrian delivers breakthrough performance and efficiency. A parallel model family to our generative flagship ESM3, Cambrian sets a new state of the art for representation learning."

"Biology is fundamentally programmable. Every living organism shares the same genetic code across the same 20 amino acids—life’s alphabet. ESM3 understands all of this biological data, translates it, and speaks it fluently to be used as a generative tool."

"Fluorescent Proteins are beautiful in their complexity. They are responsible for vibrant colors in jellyfish and corals, and have become a powerful tool in biology. With ESM3 we were able to design esmGFP, a novel version of the Green Fluorescent Protein.Generated by ESM3 with chain-of-thought prompting, esmGFP is a vast evolutionary departure from natural fluorescent proteins. It would have taken nature 500 million years to evolve this protein."

"Users input a mix of sequence, structure, or function data simultaneously, prompting ESM3 to explore a vast space of possibilities."

Key Topics & Focus Areas for evolutionaryscale.ai:

Introducing 
ESM Cambrian

Enabling scientists to understand, imagine, and create proteins.

Creating proteins beyond nature.

ESM3 simultaneously reasons over the fundamental properties of a protein: sequence, structure, and function.

A model trained across all of evolution.

Start working with ESM3